p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

Clostridium difficile toxin A causes acute neutrophil infiltration and intestinal mucosal injury. In cultured cells, toxin A inactivates Rho proteins by monoglucosylation. In monocytes, toxin A induces IL-8 production and necrosis by unknown mechanisms. We investigated the role of mitogen-activated...

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Huvudupphovsmän: Warny, Michel, Keates, Andrew C., Keates, Sarah, Castagliuolo, Ignazio, Zacks, Jeff K., Aboudola, Samer, Qamar, Amir, Pothoulakis, Charalabos, LaMont, J. Thomas, Kelly, Ciarán P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2000
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC300827/
https://ncbi.nlm.nih.gov/pubmed/10772660
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