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The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice

Induction of CD8(+) T cell immunity is a key characteristic of an effective vaccine. For safety reasons, human vaccination strategies largely use attenuated nonreplicating or weakly replicating poxvirus-based vectors, but these often elicit poor CD8(+) T cell immunity and might not result in optimal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Salek-Ardakani, Shahram, Flynn, Rachel, Arens, Ramon, Yagita, Hideo, Smith, Geoffrey L., Borst, Jannie, Schoenberger, Stephen P., Croft, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007137/
https://ncbi.nlm.nih.gov/pubmed/21183789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42056
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