Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

Biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is linked to the development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as well as other abnormalities. The VHL gene product, pVHL, is part of an E3 ubiquitin ligase complex that targets the α su...

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Bibliografiske detaljer
Main Authors: Kondo, Keiichi, Kim, William Y, Lechpammer, Mirna, Kaelin, William G
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2003
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC300692/
https://ncbi.nlm.nih.gov/pubmed/14691554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0000083
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