Ca(2+) clock malfunction in a canine model of pacing-induced heart failure

The mechanisms of sinoatrial node (SAN) dysfunction in heart failure (HF) remain unclear. We hypothesized that impaired rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release (Ca(2+) clock) plays an important role in SAN dysfunction in HF. HF was induced in canine hearts by rapid ventricular pac...

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Main Authors: Shinohara, Tetsuji, Park, Hyung-Wook, Han, Seongwook, Shen, Mark J., Maruyama, Mitsunori, Kim, Daehyeok, Chen, Peng-Sheng, Lin, Shien-Fong
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006277/
https://ncbi.nlm.nih.gov/pubmed/20889842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00723.2010
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