The active Zot domain (aa 288–293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation

Vibrio cholerae-derived zonula occludins toxin (Zot) is a multifunctional protein that reversibly disassembles intestinal tight junctions (tjs). Zot structure-function analysis has mapped this activity to aa 288–293, named AT1002. AT1002 reduced transepithelial electrical resistance across rat small...

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Detalhes bibliográficos
Main Authors: Goldblum, Simeon E., Rai, Usha, Tripathi, Amit, Thakar, Manjusha, De Leo, Luigina, Di Toro, Nicola, Not, Tarcisio, Ramachandran, Rithwik, Puche, Adam C., Hollenberg, Morley D., Fasano, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005425/
https://ncbi.nlm.nih.gov/pubmed/20852064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-158972
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