INSIGHT INTO THE MODE OF ACTION OF THE LRRK2 Y1699C PATHOGENIC MUTANT

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent known cause of autosomal dominant Parkinson's disease (PD). The LRRK2 gene encodes a Roco protein featuring a ROC GTPase and a kinase domain linked by the C-terminal of ROC (COR) domain. Here, we explored the effe...

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Detalhes bibliográficos
Main Authors: Daniëls, Veronique, Vancraenenbroeck, Renée, Law, Bernard MH, Greggio, Elisa, Lobbestael, Evy, Gao, Fangye, De Maeyer, Marc, Cookson, Mark R, Harvey, Kirsten, Baekelandt, Veerle, Taymans, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005098/
https://ncbi.nlm.nih.gov/pubmed/21073465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.07105.x
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