Modifying the Substrate Specificity of Carcinoscorpius rotundicauda Serine Protease Inhibitor Domain 1 to Target Thrombin

Protease inhibitors play a decisive role in maintaining homeostasis and eliciting antimicrobial activities. Invertebrates like the horseshoe crab have developed unique modalities with serine protease inhibitors to detect and respond to microbial and host proteases. Two isoforms of an immunomodulator...

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Detalhes bibliográficos
Main Authors: Giri, Pankaj Kumar, Tang, Xuhua, Thangamani, Saravanan, Shenoy, Rajesh T., Ding, Jeak Ling, Swaminathan, Kunchithapadam, Sivaraman, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004852/
https://ncbi.nlm.nih.gov/pubmed/21188150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015258
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