Fed-batch fermentation of GM-CSF-producing glycoengineered Pichia pastoris under controlled specific growth rate

BACKGROUND: Yeast expression systems with altered N-glycosylation are now available to produce glycoproteins with homogenous, defined N-glycans. However, data on the behaviour of these strains in high cell density cultivation are scarce. RESULTS: Here, we report on cultivations under controlled spec...

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Detalhes bibliográficos
Main Authors: Jacobs, Pieter P, Inan, Mehmet, Festjens, Nele, Haustraete, Jurgen, Van Hecke, Annelies, Contreras, Roland, Meagher, Michael M, Callewaert, Nico
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004841/
https://ncbi.nlm.nih.gov/pubmed/21092289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-9-93
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