Epigenetic-Genetic Chromosome Dosage Approach for Fetal Trisomy 21 Detection Using an Autosomal Genetic Reference Marker

BACKGROUND: The putative promoter of the holocarboxylase synthetase (HLCS) gene on chromosome 21 is hypermethylated in placental tissues and could be detected as a fetal-specific DNA marker in maternal plasma. Detection of fetal trisomy 21 (T21) has been demonstrated by an epigenetic-genetic chromos...

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Detalhes bibliográficos
Main Authors: Tong, Yu K., Chiu, Rossa W. K., Akolekar, Ranjit, Leung, Tak Y., Lau, Tze K., Nicolaides, Kypros H., Lo, Y. M. Dennis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004793/
https://ncbi.nlm.nih.gov/pubmed/21249119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015244
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