Impairment of Hepatitis B Virus Virion Secretion by Single-Amino-Acid Substitutions in the Small Envelope Protein and Rescue by a Novel Glycosylation Site

Mutations in the S region of the hepatitis B virus (HBV) envelope gene are associated with immune escape, occult infection, and resistance to therapy. We previously identified naturally occurring mutations in the S gene that alter HBV virion secretion. Here we used transcomplementation assay to conf...

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Detalhes bibliográficos
Main Authors: Ito, Kiyoaki, Qin, Yanli, Guarnieri, Michael, Garcia, Tamako, Kwei, Karen, Mizokami, Masashi, Zhang, Jiming, Li, Jisu, Wands, Jack R., Tong, Shuping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004315/
https://ncbi.nlm.nih.gov/pubmed/20881037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01499-10
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