NOVEL INHIBITOR OF FATTY ACID AMIDE HYDROLASE NORMALIZES CARDIOVASCULAR FUNCTION IN HYPERTENSION WITHOUT ADVERSE METABOLIC EFFECTS

The enzyme fatty-acid amide hydrolase (FAAH) catalyzes the in vivo degradation of the endocannabinoid anandamide, thus controlling its action at receptors. A novel FAAH inhibitor, AM3506, normalizes the elevated blood pressure and cardiac contractility of spontaneously hypertensive rats (SHR) withou...

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Bibliografiske detaljer
Main Authors: Godlewski, Grzegorz, Alapafuja, Shakiru O., Bátkai, Sándor, Nikas, Spyros P., Cinar, Resat, Offertáler, László, Osei-Hyiaman, Douglas, Liu, Jie, Mukhopadhyay, Bani, Harvey-White, Judith, Tam, Joseph, Pacak, Karel, Blankman, Jacqueline L., Cravatt, Benjamin F., Makriyannis, Alexandros, Kunos, George
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003779/
https://ncbi.nlm.nih.gov/pubmed/21095576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.08.013
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