Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury

INTRODUCTION: Earlier work indicates that the cholesterol-lowering drug, simvastatin, is anabolic to chondrogenic expression of rat intervertebral disc (IVD) cells, which suggests a potential role for simvastatin in IVD regeneration. In this study, we expand on our earlier work to test the effective...

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Autores principales: Zhang, Huina, Wang, Lin, Park, Jun Beom, Park, Paul, Yang, Victor C, Hollister, Scott J, La Marca, Frank, Lin, Chia-Ying
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003500/
https://ncbi.nlm.nih.gov/pubmed/19912653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2861
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