Phosphorylation of p50 NF-κB at a Single Serine Residue by DNA-dependent Protein Kinase Is Critical for VCAM-1 Expression upon TNF Treatment

The DNA binding activity of NF-κB is critical for VCAM-1 expression during inflammation. DNA-dependent protein kinase (DNA-PK) is thought to be involved in NF-κB activation. Here we show that DNA-PK is required for VCAM-1 expression in response to TNF. The phosphorylation and subsequent degradation...

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Autors principals: Ju, Jihang, Naura, Amarjit S., Errami, Youssef, Zerfaoui, Mourad, Kim, Hogyoung, Kim, Jong G., Elmageed, Zakaria Y. Abd, Abdel-Mageed, Asim B., Giardina, Charles, Beg, Amer A., Smulson, Mark E., Boulares, A. Hamid
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003413/
https://ncbi.nlm.nih.gov/pubmed/20966071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.158352
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