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PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model
BACKGROUND: We recently showed that PARP-1 may play a role in allergen (ovalbumin)-induced airway eosinophilia, potentially through a specific effect on IL-5 production. We also reported that while IL-5 replenishment promotes reversal of eosinophilia in lungs of PARP-1(−/−) mice, IL-4 or IgE repleni...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150522/ https://ncbi.nlm.nih.gov/pubmed/21276008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1398-9995.2011.02549.x |
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