PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model

BACKGROUND: We recently showed that PARP-1 may play a role in allergen (ovalbumin)-induced airway eosinophilia, potentially through a specific effect on IL-5 production. We also reported that while IL-5 replenishment promotes reversal of eosinophilia in lungs of PARP-1(−/−) mice, IL-4 or IgE repleni...

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Main Authors: Datta, Rahul, Naura, Amarjit S., Zerfaoui, Mourad, Errami, Youssef, Oumouna, Mustapha, Kim, Hogyoung, Ju, Jihang, Ronchi, Virginia P, Haas, Arthur L., Boulares, A. Hamid
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150522/
https://ncbi.nlm.nih.gov/pubmed/21276008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1398-9995.2011.02549.x
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