A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors

Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are, therefore, promising anti-cancer drugs. The cyclin-dependent kinase inhibitor p21 is activated in histone deacetylase (HDAC) inhibitor-treated tumor cells, and its growth-inhibitory function contributes to...

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Détails bibliographiques
Auteurs principaux: Simboeck, Elisabeth, Sawicka, Anna, Zupkovitz, Gordin, Senese, Silvia, Winter, Stefan, Dequiedt, Franck, Ogris, Egon, Di Croce, Luciano, Chiocca, Susanna, Seiser, Christian
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003405/
https://ncbi.nlm.nih.gov/pubmed/20952396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184481
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