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A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors

Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are, therefore, promising anti-cancer drugs. The cyclin-dependent kinase inhibitor p21 is activated in histone deacetylase (HDAC) inhibitor-treated tumor cells, and its growth-inhibitory function contributes to...

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מידע ביבליוגרפי
Main Authors: Simboeck, Elisabeth, Sawicka, Anna, Zupkovitz, Gordin, Senese, Silvia, Winter, Stefan, Dequiedt, Franck, Ogris, Egon, Di Croce, Luciano, Chiocca, Susanna, Seiser, Christian
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003405/
https://ncbi.nlm.nih.gov/pubmed/20952396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184481
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