A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors

Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are, therefore, promising anti-cancer drugs. The cyclin-dependent kinase inhibitor p21 is activated in histone deacetylase (HDAC) inhibitor-treated tumor cells, and its growth-inhibitory function contributes to...

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Hlavní autoři: Simboeck, Elisabeth, Sawicka, Anna, Zupkovitz, Gordin, Senese, Silvia, Winter, Stefan, Dequiedt, Franck, Ogris, Egon, Di Croce, Luciano, Chiocca, Susanna, Seiser, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003405/
https://ncbi.nlm.nih.gov/pubmed/20952396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184481
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