A Single Amino Acid in Human APOBEC3F Alters Susceptibility to HIV-1 Vif

Human APOBEC3F (huA3F) potently restricts the infectivity of HIV-1 in the absence of the viral accessory protein virion infectivity factor (Vif). Vif functions to preserve viral infectivity by triggering the degradation of huA3F but not rhesus macaque A3F (rhA3F). Here, we use a combination of delet...

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Autors principals: Albin, John S., LaRue, Rebecca S., Weaver, Jessalyn A., Brown, William L., Shindo, Keisuke, Harjes, Elena, Matsuo, Hiroshi, Harris, Reuben S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003379/
https://ncbi.nlm.nih.gov/pubmed/20971849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.173161
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