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Structural Basis for Proficient Incorporation of dTTP Opposite O(6)-Methylguanine by Human DNA Polymerase ι
O(6)-Methylguanine (O(6)-methylG) is highly mutagenic and is commonly found in DNA exposed to methylating agents, even physiological ones (e.g. S-adenosylmethionine). The efficiency of a truncated, catalytic DNA polymerase ι core enzyme was determined for nucleoside triphosphate incorporation opposi...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003365/ https://ncbi.nlm.nih.gov/pubmed/20961860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183665 |
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