Structural Basis for Proficient Incorporation of dTTP Opposite O(6)-Methylguanine by Human DNA Polymerase ι

O(6)-Methylguanine (O(6)-methylG) is highly mutagenic and is commonly found in DNA exposed to methylating agents, even physiological ones (e.g. S-adenosylmethionine). The efficiency of a truncated, catalytic DNA polymerase ι core enzyme was determined for nucleoside triphosphate incorporation opposi...

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Bibliographic Details
Main Authors: Pence, Matthew G., Choi, Jeong-Yun, Egli, Martin, Guengerich, F. Peter
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003365/
https://ncbi.nlm.nih.gov/pubmed/20961860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183665
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