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Palmitoylation-dependent association with CD63 targets the Ca(2+) sensor synaptotagmin VII to lysosomes
Syt VII is a Ca(2+) sensor that regulates lysosome exocytosis and plasma membrane repair. Because it lacks motifs that mediate lysosomal targeting, it is unclear how Syt VII traffics to these organelles. In this paper, we show that mutations or inhibitors that abolish palmitoylation disrupt Syt VII...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003310/ https://ncbi.nlm.nih.gov/pubmed/21041449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201003021 |
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