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Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells

Synaptotagmin VII (Syt VII) is a Ca(2+) sensing molecule that regulates lysosomal exocytosis in several cell types. In macrophages (MØ), Syt VII is required for efficient uptake of large particle loads, by promoting the delivery of lysosomal membrane to phagocytic cups. Here we compare the phagocyti...

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Bibliographic Details
Published in:Immunobiology
Main Authors: Becker, Steven M., Delamarre, Lélia, Mellman, Ira, Andrews, Norma W.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737586/
https://ncbi.nlm.nih.gov/pubmed/19157638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imbio.2008.11.006
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