Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages

BACKGROUND: Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood. Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in...

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Bibliografiska uppgifter
Huvudupphovsmän: Morinaga, Yoshitomo, Yanagihara, Katsunori, Nakamura, Shigeki, Hasegawa, Hiroo, Seki, Masafumi, Izumikawa, Koichi, Kakeya, Hiroshi, Yamamoto, Yoshihiro, Yamada, Yasuaki, Kohno, Shigeru, Kamihira, Shimeru
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2010
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003236/
https://ncbi.nlm.nih.gov/pubmed/21092200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-158
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