The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

Glucose and glutamine serve as the two primary carbon sources in proliferating cells, and uptake of both nutrients is directed by growth factor signaling. Although either glucose or glutamine can potentially support mitochondrial tricarboxylic acid (TCA) cycle integrity and ATP production, we found...

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Detalhes bibliográficos
Main Authors: Wellen, Kathryn E., Lu, Chao, Mancuso, Anthony, Lemons, Johanna M.S., Ryczko, Michael, Dennis, James W., Rabinowitz, Joshua D., Coller, Hilary A., Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003197/
https://ncbi.nlm.nih.gov/pubmed/21106670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1985910
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