Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity

Glutamine (GLN) plays a key role in cellular protection following injury via enhancement of heat shock protein 70 (HSP70). The pathway by which GLN enhances HSP70 is unknown. GLN is a key substrate for the hexosamine biosynthetic pathway (HBP), which has been shown to induce HSP70. We sought to expl...

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Bibliographic Details
Main Authors: Hamiel, Christine R., Pinto, Shanti, Hau, Ann, Wischmeyer, Paul E.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
Subjects:
Cellular and Mitochondrial Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793053/
https://ncbi.nlm.nih.gov/pubmed/19776393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00240.2009
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