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Metabolism strikes back: metabolic flux regulates cell signaling

Mammalian cells depend on growth factor signaling to take up nutrients; however, coordination of glucose and glutamine uptake has been a mystery. In this issue of Genes & Development, Wellen and colleagues (pp. 2784–2799) show that glucose flux through the hexosamine biosynthesis pathway regulat...

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Autori principali: Metallo, Christian M., Vander Heiden, Matthew G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003187/
https://ncbi.nlm.nih.gov/pubmed/21159812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2010510
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