Regulation of hematopoietic stem cells by their mature progeny

Thrombopoietin (TPO), acting through its receptor Mpl, has two major physiological roles: ensuring production of sufficient platelets via stimulation of megakaryocyte production and maintaining hematopoietic stem cell (HSC) quiescence. Mpl also controls circulating TPO concentration via receptor-med...

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Dettagli Bibliografici
Autori principali: de Graaf, Carolyn A., Kauppi, Maria, Baldwin, Tracey, D. Hyland, Craig, Metcalf, Donald, Willson, Tracy A., Carpinelli, Marina R., Smyth, Gordon K., Alexander, Warren S., Hilton, Douglas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003054/
https://ncbi.nlm.nih.gov/pubmed/21115812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016166108
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