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Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase

Numerous 2′-deoxynucleoside triphosphates (dNTPs) that are functionalized with spacious modifications such as dyes and affinity tags like biotin are substrates for DNA polymerases. They are widely employed in many cutting-edge technologies like advanced DNA sequencing approaches, microarrays, and si...

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Bibliographic Details
Main Authors: Obeid, Samra, Baccaro, Anna, Welte, Wolfram, Diederichs, Kay, Marx, Andreas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003043/
https://ncbi.nlm.nih.gov/pubmed/21123743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013804107
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