Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly

Src homology 3 (SH3) domains are globular protein interaction modules that regulate cell behavior. The classic SH3 ligand-binding site accommodates a hydrophobic PxxP motif and a positively charged specificity-determining residue. We have determined the NMR structure of insulin receptor tyrosine kin...

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Bibliographische Detailangaben
Hauptverfasser: Aitio, Olli, Hellman, Maarit, Kazlauskas, Arunas, Vingadassalom, Didier F., Leong, John M., Saksela, Kalle, Permi, Perttu
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003032/
https://ncbi.nlm.nih.gov/pubmed/21098279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010243107
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