BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

BACKGROUND: Basal-like breast cancers (BLBC) are aggressive breast cancers for which, so far, no targeted therapy is available because they typically lack expression of hormone receptors and HER2. Phenotypic features of BLBCs, such as clinical presentation and early age of onset, resemble those of b...

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Autori principali: Holstege, Henne, Horlings, Hugo M, Velds, Arno, Langerød, Anita, Børresen-Dale, Anne-Lise, van de Vijver, Marc J, Nederlof, Petra M, Jonkers, Jos
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002929/
https://ncbi.nlm.nih.gov/pubmed/21118481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-654
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