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Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β
AIMS: We have previously shown that 17-β-estradiol (E2) protects cardiomyocytes exposed to simulated ischaemia–reperfusion (I/R) by differentially regulating pro-apoptotic p38α mitogen-activated protein kinase (p38α MAPK) and pro-survival p38β. However, little is known about how E2 modulation of the...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3002868/ https://ncbi.nlm.nih.gov/pubmed/20724307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq265 |
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