Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions

AIM: Prostaglandin E(2), by ligation of its receptor EP4, suppresses the production of inflammatory cytokines and chemokines in macrophages in vitro. Thus, activation of EP4 may constitute an endogenous anti-inflammatory pathway. This study investigated the role of EP4 in atherosclerosis in vivo, an...

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Hlavní autoři: Tang, Eva H.C., Shimizu, Koichi, Christen, Thomas, Rocha, Viviane Z., Shvartz, Eugenia, Tesmenitsky, Yevgenia, Sukhova, Galina, Shi, Guo-Ping, Libby, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002867/
https://ncbi.nlm.nih.gov/pubmed/20736236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq262
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