Deletion of EP4 on bone marrow–derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation

OBJECTIVE: To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow-derived cells would increase local inflammation and enhance the formation of abdominal aortic aneurysm (AAA) in vivo. METHODS AND RESULTS: Prostaglandin E(2) (PGE(2)), through activation of its receptor EP4, can...

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Bibliographische Detailangaben
Hauptverfasser: Tang, Eva HC, Shvartz, Eugenia, Shimizu, Koichi, Rocha, Viviane Z, Zheng, Chunyu, Fukuda, Daiju, Shi, Guo-Ping, Sukhova, Galina, Libby, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025710/
https://ncbi.nlm.nih.gov/pubmed/21088251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.216580
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