Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5

BACKGROUND AND AIMS: Adenomatous polyposis coli (APC) is a tumour suppressor gene mutated in the germline of patients with familial adenomatous polyposis (FAP) and somatically in most colorectal cancers. APC mutations impair β-catenin degradation, resulting in increased Wnt signalling. The most freq...

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Detalhes bibliográficos
Main Authors: Lewis, Annabelle, Segditsas, Stefania, Deheragoda, Maesha, Pollard, Patrick, Jeffery, Rosemary, Nye, Emma, Lockstone, Helen, Davis, Hayley, Clark, Susan, Stamp, Gordon, Poulsom, Richard, Wright, Nicholas, Tomlinson, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2010
Assuntos:
Colon Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002835/
https://ncbi.nlm.nih.gov/pubmed/20926645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2009.193680
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