TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T cells with no measurable effect on susceptibility to SIV infection

Studies using transformed human cell lines suggest that most SIV strains use CCR5 as co-receptor. Our analysis of primary rhesus macaque CD4(+) T-cell clones revealed marked differences in susceptibility to SIV(mac)239 infection. We investigated whether different levels of CCR5 expression account fo...

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Detalhes bibliográficos
Main Authors: Minang, Jacob T., Trivett, Matthew T., Barsov, Eugene V, Del Prete, Gregory Q., Trubey, Charles M., Thomas, James A., Gorelick, Robert J., Piatak, Michael, Ott, David E., Ohlen, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001627/
https://ncbi.nlm.nih.gov/pubmed/21035160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.10.005
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