The Mamu B*17-restricted SIV Nef IW9 to TW9 mutation abrogates correct epitope processing and presentation without loss of replicative fitness

CD8(+) cytotoxic T lymphocytes (CTL) play an important role in controlling virus replication in HIV- and SIV-infected humans and monkeys, respectively. Three well-studied SIV CTL determinants are the two Mamu A*01-restricted epitopes Gag CM9 and Tat SL8, and the Mamu B*17-restricted epitope Nef IW9....

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Detalhes bibliográficos
Main Authors: Minang, Jacob T., Trivett, Matthew T., Coren, Lori V., Barsov, Eugene V., Piatak, Michael, Chertov, Oleg, Chertova, Elena, Ott, David E., Ohlen, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684690/
https://ncbi.nlm.nih.gov/pubmed/18328525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.02.005
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