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Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8(+) T cells independent of IFN-γ and CD107a responses

CD8(+) T lymphocytes (CTL) play a role in controlling HIV/SIV infection. CTL antiviral activity is dependent on recognition of antigenic peptides associated with MHC class I molecules on infected target cells, and CTL activation can be impaired by Nef-mediated down-regulation of MHC class I molecule...

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Библиографические подробности
Главные авторы: Minang, Jacob T., Trivett, Matthew T., Coren, Lori V., Barsov, Eugene V., Piatak, Michael, Ott, David E., Ohlen, Claes
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716421/
https://ncbi.nlm.nih.gov/pubmed/19555986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.06.008
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