Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins

eIF4E-binding proteins (4E-BPs) regulate translation of mRNAs in eukaryotes. However the extent to which specific mRNA targets are regulated by 4E-BPs remains unknown. We performed translational profiling by microarray analysis of polysome and monosome associated mRNAs in wild-type and mutant cells...

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Detalhes bibliográficos
Main Authors: Cridge, Andrew G., Castelli, Lydia M., Smirnova, Julia B., Selley, Julian N., Rowe, William, Hubbard, Simon J., McCarthy, John E.G., Ashe, Mark P., Grant, Christopher M., Pavitt, Graham D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001062/
https://ncbi.nlm.nih.gov/pubmed/20705650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq686
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