Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

BACKGROUND: Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-κB activation. Celastrol induces apoptosis by means of proteasome inhibition and suppresses prosta...

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Detalhes bibliográficos
Main Authors: Dai, Yao, DeSano, Jeffrey, Tang, Wenhua, Meng, Xiaojie, Meng, Yang, Burstein, Ezra, Lawrence, Theodore S., Xu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000808/
https://ncbi.nlm.nih.gov/pubmed/21170316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014153
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