ERK1/2-Dependent Vascular Endothelial Growth Factor Signaling Sustains Cyst Growth in Polycystin-2 Defective Mice

BACKGROUND & AIMS: Severe polycystic liver disease can complicate adult dominant polycystic kidney disease, a genetic disease caused by defects in polycystin-1 (Pkd1) or polycystin-2 (Pkd2). Liver cyst epithelial cells (LCECs) express vascular endothelial growth factor (VEGF) and its receptor, V...

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Main Authors: SPIRLI, CARLO, OKOLICSANYI, STEFANO, FIOROTTO, ROMINA, FABRIS, LUCA, CADAMURO, MASSIMILIANO, LECCHI, SILVIA, TIAN, XIN, SOMLO, STEFAN, STRAZZABOSCO, MARIO
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000794/
https://ncbi.nlm.nih.gov/pubmed/19766642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.09.005
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