Genetic variation in LIN28B is associated with the timing of puberty

The timing of puberty is highly variable1. We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 × 10(−8)). In independent replication studies in 16,373 women, each...

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Detalhes bibliográficos
Main Authors: Ong, Ken K, Elks, Cathy E, Li, Shengxu, Zhao, Jing Hua, Luan, Jian'an, Andersen, Lars B, Bingham, Sheila A, Brage, Soren, Smith, George Davey, Ekelund, Ulf, Gillson, Christopher J, Glaser, Beate, Golding, Jean, Hardy, Rebecca, Khaw, Kay-Tee, Kuh, Diana, Luben, Robert, Marcus, Michele, McGeehin, Michael A, Ness, Andrew R, Northstone, Kate, Ring, Susan M, Rubin, Carol, Sims, Matthew A, Song, Kijoung, Strachan, David P, Vollenweider, Peter, Waeber, Gerard, Waterworth, Dawn M, Wong, Andrew, Deloukas, Panagiotis, Barroso, Inês, Mooser, Vincent, Loos, Ruth J, Wareham, Nicholas J
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000552/
https://ncbi.nlm.nih.gov/pubmed/19448623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.382
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