A Latent Variable Partial Least Squares Path Modeling Approach to Regional Association and Polygenic Effect with Applications to a Human Obesity Study

Genetic association studies are now routinely used to identify single nucleotide polymorphisms (SNPs) linked with human diseases or traits through single SNP-single trait tests. Here we introduced partial least squares path modeling (PLSPM) for association between single or multiple SNPs and a laten...

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Main Authors: Xue, Fuzhong, Li, Shengxu, Luan, Jian'an, Yuan, Zhongshang, Luben, Robert N., Khaw, Kay-Tee, Wareham, Nicholas J., Loos, Ruth J. F., Zhao, Jing Hua
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288051/
https://ncbi.nlm.nih.gov/pubmed/22384102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031927
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