M(3)-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1

The activity of G protein-coupled receptors is regulated via hyper-phosphorylation following agonist stimulation. Despite the universal nature of this regulatory process, the physiological impact of receptor phosphorylation remains poorly studied. To address this question, we have generated a knock-...

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Main Authors: Kong, Kok Choi, Butcher, Adrian J., McWilliams, Phillip, Jones, David, Wess, Jürgen, Hamdan, Fadi F., Werry, Tim, Rosethorne, Elizabeth M., Charlton, Steven J., Munson, Sarah E., Cragg, Hannah A., Smart, Alison D., Tobin, Andrew B.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2010
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000281/
https://ncbi.nlm.nih.gov/pubmed/21078968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011651107
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