M(3)-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1

The activity of G protein-coupled receptors is regulated via hyper-phosphorylation following agonist stimulation. Despite the universal nature of this regulatory process, the physiological impact of receptor phosphorylation remains poorly studied. To address this question, we have generated a knock-...

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Detalhes bibliográficos
Main Authors: Kong, Kok Choi, Butcher, Adrian J., McWilliams, Phillip, Jones, David, Wess, Jürgen, Hamdan, Fadi F., Werry, Tim, Rosethorne, Elizabeth M., Charlton, Steven J., Munson, Sarah E., Cragg, Hannah A., Smart, Alison D., Tobin, Andrew B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000281/
https://ncbi.nlm.nih.gov/pubmed/21078968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011651107
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