M(3)-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1

The activity of G protein-coupled receptors is regulated via hyper-phosphorylation following agonist stimulation. Despite the universal nature of this regulatory process, the physiological impact of receptor phosphorylation remains poorly studied. To address this question, we have generated a knock-...

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Autors principals: Kong, Kok Choi, Butcher, Adrian J., McWilliams, Phillip, Jones, David, Wess, Jürgen, Hamdan, Fadi F., Werry, Tim, Rosethorne, Elizabeth M., Charlton, Steven J., Munson, Sarah E., Cragg, Hannah A., Smart, Alison D., Tobin, Andrew B.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000281/
https://ncbi.nlm.nih.gov/pubmed/21078968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011651107
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