Characterization of WRSs2 and WRSs3, new second-generation virG(icsA)-based Shigella sonnei vaccine candidates with the potential for reduced reactogenicity

Live, attenuated Shigella vaccine candidates, such as Shigella sonnei strain WRSS1, Shigella flexneri 2a strain SC602, and Shigella dysenteriae 1 strain WRSd1, are attenuated principally by the loss of the VirG(IcsA) protein. These candidates have proven to be safe and immunogenic in volunteer trial...

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Bibliografiske detaljer
Main Authors: Barnoy, S., Jeong, K.I., Helm, R.F., Suvarnapunya, A.E., Ranallo, R.T., Tzipori, S., Venkatesan, M.M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999844/
https://ncbi.nlm.nih.gov/pubmed/19932216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.11.001
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