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Characterization of Shigella virulence factor intracellular spread A (IcsA, or VirG) functional epitopes against S. flexneri 2a and S. sonnei invasion and adherence

ABSTRACT There are no licensed vaccines against Shigella, a leading cause of children’s diarrhea and travelers’ diarrhea. To develop a cross-protective vaccine against heterogeneous Shigella species and serotypes, we attempted to apply an epitope- and structure-based vaccinology platform, multiepito...

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Detalhes bibliográficos
Principais autores: Aashwina Madhwal, Sai Simha Reddy Vakamalla, Siqi Li, Weiping Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2025-09-01
coleção:Applied and Environmental Microbiology
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Acesso em linha:https://journals.asm.org/doi/10.1128/aem.01175-25
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