Disulfide Bond Reduction of Von Willebrand Factor by ADAMTS-13

BACKGROUND: von Willebrand factor (VWF) released from endothelial cells is rich in ultra-large (UL) multimers that are intrinsically active in binding platelets, whereas plasma-type VWF multimers require shear stress to be activated. This functional difference may be attributed to thiols exposed on...

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Autori principali: Yeh, Hui-Chun, Zhou, Zhou, Choi, Hiuwan, Tekeoglu, Senem, May, William, Wang, Christina, Turner, Nancy, Scheiflinger, Friedrich, Moake, Joel L., Dong, Jing-fei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999661/
https://ncbi.nlm.nih.gov/pubmed/20946172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2010.04094.x
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