Deficiencies in the Fanconi Anemia DNA damage Response Pathway Increase Sensitivity to HPV-Associated Head and Neck Cancer

Patients with the rare genetic disease, Fanconi Anemia (FA), are highly susceptible to squamous cell carcinomas arising at multiple anatomical sites including the head and neck region. Human papillomaviruses (HPVs), particularly HPV16, are associated with ~20% of head and neck squamous cell carcinom...

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Autores principales: Park, Jung Wook, Pitot, Henry C., Strati, Katerina, Spardy, Nicole, Duensing, Stefan, Grompe, Markus, Lambert, Paul F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999655/
https://ncbi.nlm.nih.gov/pubmed/20935219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1291
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