Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

BACKGROUND: Activating KRAS mutations are important for cancer initiation and progression; and have recently been shown to cause primary resistance to therapies targeting the epidermal growth factor receptor. Therefore, strategies are currently in development to overcome treatment resistance due to...

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Detalhes bibliográficos
Principais autores: Chun, Sang Y, Johnson, Craig, Washburn, Joseph G, Cruz-Correa, Marcia R, Dang, Duyen T, Dang, Long H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999617/
https://ncbi.nlm.nih.gov/pubmed/21073737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-293
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