HIF-1α and HIF-2α have divergent roles in colon cancer

Hypoxia-inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors that mediate the cellular response to hypoxia. Their key regulatory subunits, HIF-1α and HIF-2α, are induced similarly by hypoxia, but their functional roles in cancer may be distinct and isoform-specific. SW480 colon...

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Detalhes bibliográficos
Main Authors: Imamura, Takaaki, Kikuchi, Hirotoshi, Herraiz, Maria-Teresa, Park, Do-Youn, Mizukami, Yusuke, Mino-Kenduson, Mari, Lynch, Maureen P., Rueda, Bo R., Benita, Yair, Xavier, Ramnik J., Chung, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682346/
https://ncbi.nlm.nih.gov/pubmed/19030186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24032
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