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Inhibition of the Type 2 Iodothyronine Deiodinase Underlies the Elevated Plasma TSH Associated with Amiodarone Treatment

The widely prescribed cardiac antiarrhythmic drug amiodarone (AMIO) and its main metabolite, desethylamiodarone (DEA), have multiple side effects on thyroid economy, including an elevation in serum TSH levels. To study the AMIO effect on TSH, mice with targeted disruption of the type 2 deiodinase ge...

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Bibliografiset tiedot
Päätekijät: Rosene, Matthew L., Wittmann, Gábor, Arrojo e Drigo, Rafael, Singru, Praful S., Lechan, Ronald M., Bianco, Antonio C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Endocrine Society 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999495/
https://ncbi.nlm.nih.gov/pubmed/20926587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0553
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