Inhibition of the Type 2 Iodothyronine Deiodinase Underlies the Elevated Plasma TSH Associated with Amiodarone Treatment

The widely prescribed cardiac antiarrhythmic drug amiodarone (AMIO) and its main metabolite, desethylamiodarone (DEA), have multiple side effects on thyroid economy, including an elevation in serum TSH levels. To study the AMIO effect on TSH, mice with targeted disruption of the type 2 deiodinase ge...

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Detalhes bibliográficos
Main Authors: Rosene, Matthew L., Wittmann, Gábor, Arrojo e Drigo, Rafael, Singru, Praful S., Lechan, Ronald M., Bianco, Antonio C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999495/
https://ncbi.nlm.nih.gov/pubmed/20926587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0553
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