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Translocation of Borrelia burgdorferi Surface Lipoprotein OspA Through the Outer Membrane Requires an Unfolded Conformation and Can Initiate at the C-terminus

Borrelia burgdorferi surface lipoproteins are essential to the pathogenesis of Lyme borreliosis, but the mechanisms responsible for their localization are only beginning to emerge. We have previously demonstrated the critical nature of the amino-terminal ‘tether’ domain of the mature lipoprotein for...

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Библиографические подробности
Главные авторы: Schulze, Ryan J., Chen, Shiyong, Kumru, Ozan S., Zückert, Wolfram R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999405/
https://ncbi.nlm.nih.gov/pubmed/20398211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07172.x
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